Lee, county, east-central South Carolina, U.S. The northern and northwestern portions lie within the sandhills of the Fall Line zone, while the remainder of the county consists of a generally flat region on the Coastal Plain. The Lynches River forms parts of both the southeastern and northern boundaries. Lee county is also drained by the Black River. Lee State Park lies along the Lynches River.

In 2019, Lee County, SC had a population of 17.4k people with a median age of 41.8 and a median household income of $32,371. Between 2018 and 2019 the population of Lee County, SC declined from 17,606 to 17,365, a −1.37% decrease and its median household income grew from $31,651 to $32,371, a 2.27% increase.

99.3% of the residents in Lee County, SC are U.S. citizens.

In 2019, the median property value in Lee County, SC was $78,800, and the homeownership rate was 74.7%. Most people in Lee County, SC drove alone to work, and the average commute time was 25.6 minutes. The average car ownership in Lee County, SC was 2 cars per household.

Lee County, SC borders Darlington County, SC, Florence County, SC, Kershaw County, SC, and Sumter County, SC.